Endocrine Abstracts

The presence of the enzymes of local metabolism of glucocorticoids in lymphoid organs and many other tissues suggests that the local glucocorticoid signal is not determined only by plasma level of glucocorticoids but also by the local activity of these enzymes. Using resident-intruder test the present study determined if chronic social stress modulates local metabolism of corticosterone and 11-dehydrocorticosterone in rats of Fisher 344 (F344) and Lewis (LEW) strains, which di...

Stressful experiences produce profound physiological and behavioural disturbances that may contribute to many psychiatric disorders. Stress activates HPA axis whose end products glucocorticoids modulate immune cells and cytokine activity. Local effect of glucocorticoids depends not only on its concentration but also on the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11HSD1), which amplifies intracellular glucocorticoid concentration by the conversion of inactive 11-de...